Browse wiki

jump-to-nav Jump to: navigation, search

SE Authors	Miyako Kusano, Henning Redestig, Tadayoshi Hirai, Akira Oikawa, Fumio Matsuda, Atsushi Fukushima, Masanori Arita, Shin Watanabe, Megumu Yano, Kyoko Hiwasa-Tanase, Hiroshi Ezura, Kazuki Saito
SE Description	We propose using multiple analytical platf … We propose using multiple analytical platforms for the direct acquisition of an interpretable data set of estimable chemical diversity. As an example, we report an application of our multi-platform approach that assesses the substantial equivalence of tomatoes over-expressing the taste-modifying protein miraculin. In combination, the chosen platforms detected compounds that represent 86% of the estimated chemical diversity of the metabolites listed in the LycoCyc database. Following a proof-of-safety approach, we show that w92% had an acceptable range of variation while simultaneously indicating a reproducible transformation-related metabolic signature. We conclude that multi-platform metabolomics is an approach that is both sensitive and robust and that it constitutes a good starting point for characterizing genetically modified organisms. acterizing genetically modified organisms.
SE ID	SE53 +
SE Reference	Kusano M et al. (2011) PLOS ONE 6: e16989
SE Title	Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment +
Modification dateThis property is a special property in this wiki.	18 April 2018 01:58:14 +

	No properties link to this page.